At the University of Charité-Universit tsmedizin in Berlin, the largest medical school in Europe, researchers are working hard to prove that in special cases, 3D printed titanium mesh stents can replace the traditional bone grafting techniques used by patients' own bones. 3D printed titanium mesh stent treatment is particularly effective when treating a wide range of bone defects due to severe limb trauma. In addition to unparalleled strength, 3D printed titanium implants can be designed in a 1:1 ratio to suit treatment. Due to the complex internal geometry, in many cases, such implants have been shown to be more effective in promoting the ingrowth of bone and vascular structures necessary for complete recovery of the patient. To prove their hypothesis, Charité's researchers successfully conducted a large animal study using a 3D printed titanium mesh scaffold and 27 sheep. The study then turned to preclinical trials in 19 human patients. Scientific translational medicine published the results. Mechanical and biooptimized grid The titanium mesh bracket in the Charité study was 3D printed by DePuySynthes using a metal laser sintering process. The implant is designed as a honeycomb structure. By changing the support diameter of the honeycomb, researchers can create a harder implant with maximum support. The team also tried two implant reinforcement mechanisms; a shield and a locking platen (LCP), as shown below. A "soft" and "hard" 3D titanium bracket design compared to a shield or lock compression plate (LCP) reinforcement. At 24 weeks after surgery, the titanium mesh scaffold was confirmed to "enhance bone regeneration" when implanted in sheep. Therefore, a preclinical approach to human patients was subsequently decided. At 24 weeks after implantation of the sheep, X-rays showing the ingrowth of the titanium mesh were shown. Detailed information can be found online in the paper "Sheep Experiment: Mechanobiologically Optimized 3D Titanium Mesh Scaffolds Enhance Key Segment Defects in Bone Regeneration." This study was co-authored by Anne-Marie Pobloth, SaraCheca, HajarRazi, Ansgar Petersen, James C. Weaver, Katharina Schmidt-Bleek, Markus Windolf, Andrasá. Tatai, Claudia P. Roth, Klaus-Dieter Schaser, Georg N. Duda and Philipp Schwabe. The Charité-Universit tsmedizin in Berlin collaborated with the Max Planck Institute for Colloid and Interface, the Wyss Institute, the Davos AO Institute and the Dresden University of Technology.
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