Scientists at the Institute of Regenerative Medicine at the Wake Forest Baptist Medical Center in the United States have modified a stem cell by genetic engineering to express a common herpes virus protein, which can avoid attacks by the immune system and greatly improve survival rates. Injured or diseased tissues can therefore spend more time to exert their healing ability and be cured. Related papers were published in the recently published "Public Science Library · Comprehensive". "Basically we are helping the stem cells to" steal ", so that the body's natural" killer "T cells and the immune system" see "them, so that they can survive and promote physical recovery." Gray, senior author of the paper and professor of regenerative medicine Ka Almeida-Prada explained, "Stem cells are inherently capable of helping to regulate the immune response. If they can increase their survival rate, they can theoretically be used as a therapeutic measure to reduce inflammation and help organ transplant patients avoid rejection. Wait." The study used mesenchymal stem cells (MSCs), which are found in tissues such as bone marrow, peripheral blood and cord blood, fetal liver and lung. These cells are special in immune regulation and nutrition, and can preferentially migrate to injured body tissues to promote wound healing. But MSCs, like other cells, are easily killed by the body's immune system. The common virus is human cytomegalovirus (HCMV), which is one of the members of the herpes virus family. It can be latent in the human body for a long time without causing disease. "We want to use this virus' ability to evade the immune system." Almeida-Prada said, "The way is to modify the cells to make them produce the same protein as HCMV, so that they will not be killed. The researchers extracted MSCs from human fetal liver tissues and genetically engineered them to produce special proteins expressed by the HMCV virus. In this process, they identified the protein that most effectively increases the survival rate of cells-the US2 protein, and proved for the first time that overexpression of the US2 protein will reduce the ability of the immune system to recognize the cells, increasing their survival rate by approximately 59% . "Research shows that the survival rate of genetically modified cells is greatly improved." Almeida-Prada said, "The next step, we hope for their potential in the treatment of intestinal diseases, traumatic brain injury and healing of human organ transplantation. to evaluate."
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