Recently, the kick-off meeting of the 2012 national major scientific research project "protein production, modification and quality control" was held in Beijing. The chief scientist of the project is the British scholar Sarah Perrett of the Institute of Biophysics of the Chinese Academy of Sciences. The project will mainly carry out the quality control of cells in protein synthesis, folding, repair, degradation and modification. Research on key scientific issues such as the control system regulation, the impact of abnormal protein modification on the quality control system and the mechanism of occurrence and development of related diseases.

Protein is the executor of life activities, and protein quality control disorders are closely related to neurodegenerative diseases. Carrying out systematic research on protein production, modification and quality control will strengthen the overall understanding of the entire process from protein production to degradation in the cell, and more systematically explain the occurrence and development mechanism of protein misfolding related diseases such as neurodegenerative diseases , To provide new theoretical basis for the diagnosis of related diseases and drug development.

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