China Education Equipment Purchasing Network News: Tumor is a new organism formed by abnormal growth of clonality in a cell of a local tissue at the genetic level due to various carcinogenic factors. . It is generally believed that tumor cells are monoclonal, that is, all tumor cells in a tumor are the descendants of a mutant cell. Tumors are generally divided into two categories, benign and malignant. All malignant tumors are collectively called cancer. Researchers from Tianjin Medical University recently published the title "Promotion" in the internationally renowned journal "Hepatology" (currently with an impact factor of 10.84, ranking second in 65 international journals of gastrointestinal and hepatology). of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: A study of hepatocellular carcinoma ". The corresponding author of the article is the well-known pathologist Professor Sun Cunchun. He is currently the director of the Department of Pathology of Tianjin Medical University and the deputy director of Tianjin Cancer Institute. His main research directions are tumor pathological diagnosis and tumor angiogenesis, and he has undertaken 15 projects including the national "863" plan, the National Natural Science Foundation of China, the Doctoral Fund of the Ministry of Education, and the major scientific and technological development projects in Tianjin. In recent years, more than 200 papers have been published, of which 27 are included in SCI. The paper was successively read at the American Clinical Oncology Annual Meeting and the American-Canada Pathology Annual Meeting, and was cited by Nature review, Hepatology, Cancer Research, etc. The anti-apoptotic protein Bcl-2 plays various roles in apoptosis, immunity and autophagy. Its expression in tumors is related to tumor grade and malignancy. The recurrence of normally developing epithelial-mesenchymal transition (EMT) processes contributes to the plasticity of tumor cells, which is also characteristic of metastatic cells and angiogenesis mimicry. In this article, the researchers analyzed the relationship between Bcl-2 and EMT-regulated transcription factor Twist1 and tumor metastasis and angiogenesis mimicry, as well as the interaction between the two in function and structure. The researchers confirmed that BCL-2 and Twist1 can be co-expressed under hypoxic conditions. In experiments in vitro and in vivo, the researchers confirmed that BCL-2 can bind to Twist1. This interaction is related to the helix-loop-helix DNA binding domain of TWIST1 and acts through two separate domains of the Bcl-2 protein. The formation of Bcl-2 / Twist1 complex is conducive to the nuclear transport of TWIST1 and can increase the activation of a wide range of tumor genes, which are closely related to the formation, metastasis and angiogenesis mimicry of tumor cells. In addition, the researchers also confirmed that the nuclear expression of Bcl-2 and Twist1 is related to the low survival rate of 97 patients in a liver cancer study. New research shows that Bcl-2 plays an important role in EMT induction and tumor development, and provides a potential new therapeutic target for the development of new chemotherapeutic drugs, Bcl-2 / Twist1. In the treatment of tumors: diagnosis-imaging methods Diagnostic-imaging methods Mainly include X-ray imaging instruments, CT (general CT, spiral CT), positron scan (PET), ultrasound (sub-B ultrasound, color Doppler ultrasound, color Doppler ultrasound, three-dimensional color Doppler ultrasound), magnetic resonance imaging (MRI), electrocardiography , EEG instruments, etc. Radiotherapy Radiotherapy Radiation therapy can be referred to as "radiotherapy" for short. It is one of the three major treatments for cancer. It is a treatment method that irradiates tumors with various energy rays to suppress and kill cancer cells. Radiotherapy can be used alone or in conjunction with surgery, chemotherapy, etc. as part of comprehensive treatment to improve the cure rate of cancer. Before the operation, a period of radiotherapy is used to reduce the size of the tumor, so that the patients who cannot be operated can win the opportunity for surgery. For advanced cancer, palliative radiotherapy can be used to relieve pressure and relieve pain. (Xie Yinan / Editor)
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